Why the study?
Chronic hyperglycemia is implicated in impaired microvascular structure and function, but its effect on local hemodynamics and blood flow redistribution during hyperinsulinemia in T2D models remains unclear.
Does intravenous insulin and glucose alter microvascular blood flow in skeletal muscle capillary networks in a rat model of T2D?
Population
Four 12-week-old Zucker Diabetic Fatty rats (2 lean, 2 obese)
Comparison
Euglycemic hyperinsulinemia vs baseline conditions
Design
Randomized preclinical animal study
Authors
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Hyperglycemia effects on muscle capillary flow in T2D models warrant clinical caution; leaves open translation to human hyperinsulinemia responses.
Does intravenous insulin and glucose alter microvascular blood flow in skeletal muscle capillary networks in a rat model of T2D?
Obese ZDF rats exhibit an impaired capillary flow response (decreased RBC supply rate) compared to lean controls, suggesting microvascular dysfunction in T2D.
Shogan et al. (2019) studied this question.
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