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May 7, 2014Journal of Cardiothoracic SurgeryOpen Access

The effects of a low international normalized ratio on thromboembolic and bleeding complications in patients with mechanical mitral valve replacement

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Why the study?

Does a low target INR (2.0-2.5) reduce thromboembolic and bleeding complications in patients with mechanical mitral valve replacement on warfarin therapy?

Population

135 patients who underwent mechanical mitral valve replacement (MVR) on warfarin therapy

Comparison

Warfarin therapy with a mean international… vs Warfarin therapy with a mean INR <2.0 or >2.5

Design

Cohort

Follow-up

mean 39.6 months

Authors

UBU. BalAAAlp AydınalpKYKerem Can Yılmaz

Discussion

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Overview

May support INR 2.0-2.5 target in mechanical mitral valve patients; hypothesis-generating, needs randomized confirmation.

Structured PICO

Does a low target INR (2.0-2.5) reduce thromboembolic and bleeding complications in patients with mechanical mitral valve replacement on warfarin therapy?

P
Population
135 patients who underwent mechanical mitral valve replacement (MVR) on warfarin therapy
I
Intervention
Warfarin therapy with a mean international normalized ratio (INR) of 2.0-2.5
C
Comparator
Warfarin therapy with a mean INR <2.0 or >2.5
O
Outcome
Thromboembolic events (valve thrombosis, transient ischemic attack, stroke) and bleeding (all minor and major bleeding) complications at mean 39.6 months follow-uphard clinical

A lower target INR of 2.0-2.5 may be safe and effective for minimizing both thromboembolic and bleeding complications in patients with mechanical mitral valve replacement.

Cite This Study

Bal et al. (2014) studied this question.

synapsesocial.com/papers/6a714296ac440176ef29ef82https://doi.org/10.1186/1749-8090-9-79
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