September 22, 2003Cardiovascular Research

Phosphoinositide 3-kinase γ-deficient hearts are protected from the PAF-dependent depression of cardiac contractility

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Why the study?

Does PI3Kgamma deficiency protect against PAF-dependent depression of cardiac contractility following ischemia?

Structured PICO

Does PI3Kgamma deficiency protect against PAF-dependent depression of cardiac contractility following ischemia?

Population

Isolated electrically driven atria and Langendorff-perfused whole hearts derived from wild-type and PI3Kgamma-null mice

Intervention

Platelet-activating factor (PAF) stimulation, or 30 min of ischemia followed by 40 min of reperfusion in the presence or absence of PAF receptor antagonist WEB 2170

Comparator

Wild-type hearts vs PI3Kgamma-null hearts; presence vs absence of PAF receptor antagonist

Outcome

Negative inotropic effect and postischemic recovery of contractilitysurrogate

PI3Kgamma and NOS3 mediate a PAF-dependent signaling pathway that contributes to postischemic contractile depression, identifying a potential mechanism for targeted intervention in ischemic injury.

Discussion

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Implication

PI3Kgamma may represent a target to limit postischemic contractile depression; leaves open translation to human therapeutics.

Cite This Study

Giuseppe Alloatti (2003) studied this question.

synapsesocial.com/papers/6a7145edce524a4339c4d751 https://doi.org/10.1016/j.cardiores.2003.08.008

Topics

Dual antiplatelet therapy

View Full Paper

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Phosphoinositide 3-kinase γ-deficient hearts are protected from the PAF-dependent depression of cardiac contractility

Structured PICO

Discussion

Implication

Cite This Study

Topics

Phosphoinositide 3-kinase γ-deficient hearts are protected from the PAF-dependent depression of cardiac contractility

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider