Antifungal Constituents of the Essential Oil Fraction of Artemisia dracunculus L. Var. dracunculus

The isolation and structure elucidation of antifungal constituents of the steam-distilled essential oil fraction of Artemisia dracunculus are described. Antifungal activities of 5-phenyl-1,3-pentadiyne and capillarin against Colletrotichum fragariae, Colletrotichum gloeosporioides, and Colletrotichum acutatum are reported for the first time. The relative abundance of 5-phenyl-1,3-pentadiyne is about 11% of the steam-distilled oil, as determined by GC−MS. Methyleugenol was also isolated and identified as an antifungal constituent of the oil.