Population
Rat glomeruli and rabbit inner medullary collecting duct (IMCD) cells
Comparison
Brain natriuretic peptide (BNP) vs Atrial natriuretic peptide (ANP)
Design
Preclinical
Authors
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Supports direct renal BNP effects in animal models; leaves open translation to human cardiorenal disease.
BNP binds to ANP receptors in the kidney with high affinity and mimics ANP's physiological effects, including guanylate cyclase stimulation and sodium uptake inhibition.
Gunning et al. (1990) studied this question.
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