August 6, 2007Journal of Hypertension

Upregulation of AT1 receptor gene on activation of protein kinase Cβ/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla

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Population

Sprague-Dawley rats

Design

Preclinical

Authors

SCSamuel H.H. ChanPrincess Alexandra Hospital WLWang Ling-linWuhan University HTHuey-Ling Tseng

Discussion

Member takes

Implication

May identify central targets for Ang II hypertension; hypothesis-generating in animals and leaves open human translation.

Structured PICO

Population

Sprague-Dawley rats

Intervention

Microinjection of angiotensin II bilaterally into the rostral ventrolateral medulla (RVLM), with or without PKC inhibitors or antisense oligonucleotides (ASON) against PKCbeta, ERK1/2, CREB, or c-fos

Outcome

Long-term pressor effect and AT1R expression in the ventrolateral medullasurrogate

The PKCbeta/NADPH oxidase/ERK1/2/CREB/c-fos cascade represents a novel signaling pathway mediating the long-term pressor effect of angiotensin II in the rostral ventrolateral medulla.

Cite This Study

Chan et al. (2007) studied this question.

synapsesocial.com/papers/6a714658fe4101aa97e08121 https://doi.org/10.1097/hjh.0b013e328217b286

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