January 1, 1989Circulation Research

Electrophysiological and anatomic differences between canine hearts with inducible ventricular tachycardia and fibrillation associated with chronic myocardial infarction.

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Population

106 dogs studied 7-21 days after left anterior descending coronary artery ligation

Comparison

Programmed ventricular stimulation vs Comparison between dogs with inducible…

Design

Preclinical

Follow-up

7-21 days post-ligation

Authors

ADA. Robert DennissThe University of Sydney DRDavid RichardsUniversity of Technology Sydney JWJUDITH A. WAYWOODThe University of Sydney

Discussion

Member takes

Implication

Distinguishes VT from VF substrates in canine chronic MI; leaves open translation to human risk stratification.

Structured PICO

Population

106 dogs studied 7-21 days after left anterior descending coronary artery ligation (40 with inducible VT, 19 with inducible VF, 47 with no inducible arrhythmias)

Intervention

Programmed ventricular stimulation (to induce VT or VF)

Comparator

Comparison between dogs with inducible ventricular tachycardia (VT), inducible ventricular fibrillation (VF), and no inducible arrhythmias

Outcome

Electrophysiological differences (ventricular activation time in sinus rhythm via cardiac mapping) and anatomic differences (infarct size and anatomy at the infarct edge via post-mortem pathology)surrogate

In a canine model of chronic myocardial infarction, inducible ventricular tachycardia is associated with longer epicardial activation times, larger infarct sizes, and larger viable muscle bundles at the infarct edge compared to inducible ventricular fibrillation.

Cite This Study

Denniss et al. (1989) studied this question.

synapsesocial.com/papers/6a71469be36a167817e31bb7 https://doi.org/10.1161/01.res.64.1.155

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Electrophysiological and anatomic differences between canine hearts with inducible ventricular tachycardia and fibrillation associated with chronic myocardial infarction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiological and anatomic differences between canine hearts with inducible ventricular tachycardia and fibrillation associated with chronic myocardial infarction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider