Population
Chemically (saponin) skinned rat myocardium (cardiac trabeculae)
Comparison
Halothane (0.47, 1.89, and >5 mM) vs Control conditions (absence of halothane)
Design
Preclinical
Authors
Loading...
May contribute to halothane cardiotoxicity via RyR; leaves open translation to intact myocardium or clinical use.
Halothane stimulates Ca2+ efflux via the Ruthenium Red-sensitive sarcoplasmic reticulum Ca2+-release channel at lower doses, but causes irreversible membrane damage at higher doses.
Herland et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: