The sarcoplasmic reticulum plays an important role in the pathogenesis of malignant hyperthermia, with MH-susceptible pigs showing increased sensitivity to calcium release.
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Supports SR calcium hypersensitivity in porcine MH; hypothesis-generating for dantrolene mechanisms, pending human validation.
Calcium-induced calcium release and halothane-induced calcium release from pig sarcoplasmic reticulum (SR) were studied. The SR prepared from pigs susceptible to malignant hyperthermia (MH) was shown to release calcium at a much lower level of calcium content than in normal pig SR. The concentration above which halothane can release calcium is 40 microM for both MH-SR and normal SR, although the latter required a high calcium content to demonstrate the calcium release. Dantrolene was shown to inhibit the halothane-induced calcium release. Results suggest that SR plays an important role in pathogenesis of MH.
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Ohnishi et al. (1983) studied this question.
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