Key result
Malignant hyperpyrexia-susceptible pig muscle exhibited significantly smaller mean calcium currents and asymmetric charge movement compared to normal muscle, which were reduced by 50% with halothane.
Why the study?
Does halothane affect calcium currents and asymmetric charge movement in malignant hyperpyrexia-susceptible pig muscle fibers?
Population
Control pigs and pigs susceptible to malignant hyperpyrexia (MH) (gracilis muscle fibers)
Comparison
Halothane (1% v/v) vs Normal muscle / baseline without halothane
Design
Preclinical
Authors
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Should not yet change anesthetic practice; hypothesis-generating for excitation-contraction coupling defects in malignant hyperpyrexia.
Does halothane affect calcium currents and asymmetric charge movement in malignant hyperpyrexia-susceptible pig muscle fibers?
The findings suggest that the signal coupling depolarization to calcium release from the sarcoplasmic reticulum is abnormal in malignant hyperpyrexia-susceptible muscle.
Lamb et al. (1989) studied Malignant hyperpyrexia. Malignant hyperpyrexia susceptibility vs. Normal muscle (control pigs) was evaluated on Calcium current (ICa) and asymmetric charge movement. Malignant hyperpyrexia-susceptible pig muscle exhibited significantly smaller mean calcium currents and asymmetric charge movement compared to normal muscle, which were reduced by 50% with halothane.
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