Population
Purified malignant hyperthermia-susceptible and normal pig sarcoplasmic reticulum Ca2+ release channels
Comparison
Caffeine stimulation at varying pH and Ca2+… vs Normal pig Ca2+ release channels
Design
Preclinical
Authors
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pH sensitivity differs in mutant porcine MHS channels without direct caffeine effects; leaves open indirect mechanisms in malignant hyperthermia.
The Arg615-to-Cys615 mutation in the porcine SR Ca2+ release channel is not directly responsible for the altered caffeine sensitivity seen in malignant hyperthermia.
Shomer et al. (1994) studied this question.
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