Population
Malignant hyperthermia-susceptible (MHS) and normal porcine myotubes
Comparison
Whole cell patch-clamp technique to record… vs Normal porcine myotubes
Design
Preclinical
Authors
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Challenges presumed L-type Ca current reduction in MHS; leaves open RYR1 mutation effects on muscle development via other mechanisms.
The L-type calcium current is not reduced in MHS porcine myotubes, suggesting no direct relationship between the SR Ca2+-release channel mutation and muscle development regarding this current.
Gallant et al. (1996) studied this question.
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