Key result
The rate of sarcoplasmic reticulum Ca2+ release was consistently higher in malignant hyperthermia-susceptible porcine muscle triads compared to normal triads at submaximal doses of release triggers.
Why the study?
Does the sarcoplasmic reticulum Ca2+ release channel activity differ between normal and malignant hyperthermia-susceptible porcine skeletal muscle triads upon direct or indirect stimulation?
Population
Triad vesicles isolated from normal and homozygous malignant hyperthermia-susceptible porcine skeletal muscle
Comparison
Polylysine-induced Ca2+ release and… vs Normal porcine skeletal muscle triads
Design
Preclinical
Authors
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Does not inform human MH management; leaves open translation of enhanced porcine Ca2+ release to clinical disease.
Does the sarcoplasmic reticulum Ca2+ release channel activity differ between normal and malignant hyperthermia-susceptible porcine skeletal muscle triads upon direct or indirect stimulation?
The sarcoplasmic reticulum Ca2+ release channel activity is intrinsically higher in malignant hyperthermia-susceptible porcine muscle compared to normal muscle when stimulated directly or indirectly.
El-Hayek et al. (1995) studied Malignant hyperthermia susceptibility. Polylysine and depolarization-induced stimulation vs. Normal porcine skeletal muscle was evaluated on Rate of induced Ca2+ release. The rate of sarcoplasmic reticulum Ca2+ release was consistently higher in malignant hyperthermia-susceptible porcine muscle triads compared to normal triads at submaximal doses of release triggers.
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