Population
Isolated malignant hyperthermia-susceptible porcine heavy sarcoplasmic reticulum and intact fiber bundles
Comparison
[3H]ryanodine binding assay and ryanodine exposure vs Normal porcine SR and normal muscle
Design
Preclinical
Authors
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May implicate ryanodine receptor dysfunction in malignant hyperthermia; hypothesis-generating in porcine models and leaves open human translation.
Abnormalities in the skeletal muscle ryanodine receptor may be responsible for the abnormal sarcoplasmic reticulum calcium release and contractile properties seen in malignant hyperthermia.
Mickelson et al. (1988) studied this question.
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