April 13, 1992FEBS Letters

Structural and functional correlates of a mutation in the malignant hyperthermia‐susceptible pig ryanodine receptor

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Population

Isolated sarcoplasmic reticulum membranes from malignant hyperthermia-susceptible pigs with the Arg615 to…

Design

Preclinical

Authors

JMJames R. MickelsonWashington State University CKC. Michael KnudsonUniversity of Iowa CKCatharine F. KennedyBaylor College of Medicine

Discussion

Member takes

Implication

Does not support clinical translation; leaves open ryanodine receptor domain mapping in malignant hyperthermia models.

Structured PICO

Population

Isolated sarcoplasmic reticulum (SR) membranes from malignant hyperthermia-susceptible (MHS) pigs with the Arg615 to Cys615 mutation in the skeletal muscle ryanodine receptor

Intervention

Trypsin treatment

Outcome

Alteration of tryptic peptide map and release of ryanodine receptor fragmentssurrogate

The Arg615 to Cys615 mutation in the ryanodine receptor of MHS pigs alters tryptic cleavage, indicating the 86-99 kDa domain is near the cytoplasmic surface and likely near important Ca2+ channel regulatory sites.

Cite This Study

Mickelson et al. (1992) studied this question.

synapsesocial.com/papers/6a75a4e5b0b151b091e8c674 https://doi.org/10.1016/0014-5793(92)80208-x

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Structural and functional correlates of a mutation in the malignant hyperthermia‐susceptible pig ryanodine receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural and functional correlates of a mutation in the malignant hyperthermia‐susceptible pig ryanodine receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider