Population
Normal and MH-susceptible (MHS) pig skeletal muscles with an Arg615-->Cys mutation
Comparison
DP4, a domain peptide matching the… vs No added peptide / normal muscle RyR1 channels
Design
Preclinical
Authors
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May implicate disrupted RyR1 inter-domain interactions in MH; animal data leave open clinical relevance and therapeutic targeting.
The study suggests that affected inter-domain interaction between regions 1 and 2 of the RyR1 channel underlies the dysfunction of Ca2+ homeostasis in malignant hyperthermia.
Murayama et al. (2007) studied this question.
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