May 28, 2008Journal of Biological ChemistryOpen Access

Reduced Threshold for Luminal Ca2+ Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia

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Population

HEK293 cells expressing the porcine malignant hyperthermia mutation R615C in the RyR1 channel, and wild type…

Comparison

Halothane and Dantrolene vs Wild type RyR1 and RyR2 mutant

Design

Preclinical

Authors

DJDawei Jiang82th Hospital of Pla WCWenqian ChenZhejiang Chinese Medical University JXJianmin XiaoXi'an University of Architecture and Technology

Discussion

Member takes

Implication

Supports dantrolene suppression of SOICR in MH models; leaves open translation to human RyR1-targeted therapies.

Structured PICO

Population

HEK293 cells expressing the porcine malignant hyperthermia mutation R615C in the RyR1 channel, and wild type RyR1

Intervention

Halothane and Dantrolene

Comparator

Wild type RyR1 and RyR2 mutant

Outcome

Threshold for store overload-induced Ca2+ release (SOICR) and luminal Ca2+ activation of RyR1surrogate

The R615C mutation confers malignant hyperthermia susceptibility by reducing the threshold for luminal Ca2+ activation and SOICR, providing a causal mechanism for the disease.

Cite This Study

Jiang et al. (2008) studied this question.

synapsesocial.com/papers/6a70c0e3f44fa9f079de731e https://doi.org/10.1074/jbc.m801944200

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Reduced Threshold for Luminal Ca2+ Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reduced Threshold for Luminal Ca2+ Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider