Population
Myoblastic cells transfected with either wild-type or mutated (Arg615-->Cys) ryanodine receptor cDNA
Comparison
Expression of mutated ryanodine receptor and… vs Cells expressing wild-type ryanodine receptor…
Design
Preclinical
Authors
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Supports MH causality of the mutation in cellular models; hypothesis-generating for human anesthetic risk without clinical practice change.
The Arg615-->Cys mutation in the ryanodine receptor directly causes hypersensitivity to caffeine and halothane, providing definitive evidence that it is causative of malignant hyperthermia.
Otsu et al. (1994) studied this question.
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