April 30, 2012Proceedings of the National Academy of SciencesOpen Access

Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca ²⁺ channel and the type 1 ryanodine receptor

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Structured PICO

Population

dysgenic (Ca(V)1.1 null) myotubes

Intervention

Expression of Ca(V)1.1 mutation R174W

Comparator

Myotubes expressing wild-type Ca(V)1.1

Outcome

Functional consequences including L-type current, EC coupling, sensitivity of Ca(2+) release to caffeine and volatile anesthetics, resting myoplasmic Ca(2+) levels, and sarcoplasmic reticulum (SR) storessurrogate

The Ca(V)1.1 R174W mutation sensitizes muscle cells to malignant hyperthermia triggers by perturbing the negative regulation of RyR1 leak, identifying a unique mechanism for MH susceptibility.

Discussion

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Implication

R174W may heighten MH trigger sensitivity via RyR1 leak in models; leaves open clinical relevance for human mutation carriers.

Cite This Study

Eltit et al. (2012) studied this question.

synapsesocial.com/papers/6a1d0cc9d676c7290baf2d45 https://doi.org/10.1073/pnas.1119207109

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Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca ²⁺ channel and the type 1 ryanodine receptor

Structured PICO

Discussion

Implication

Cite This Study

Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca ²⁺ channel and the type 1 ryanodine receptor

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider