Bastadin 5 partially restores the elevated resting intracellular calcium in myotubes expressing malignant hyperthermia RyR1 mutations, suggesting a mechanism of passive calcium leak from the sarcoplasmic reticulum.
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Supports passive Ca²⁺ leak via mutant RyR1 in MH models; leaves open whether bastadin analogs merit clinical investigation.
Yang et al. (2006) studied this question.
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