Population
Porcine myotubes from normal pigs and cells from specimens homozygous for the Arg615Cys mutation of the…
Comparison
Arg615Cys mutation of the skeletal muscle… vs Myotubes from normal pigs (controls)
Design
Preclinical
Authors
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May explain MH-related Ca2+ dysregulation; leaves open human applicability and therapeutic implications.
The Arg615Cys mutation in the skeletal muscle ryanodine receptor RyR1 shifts the voltage dependence of Ca2+ release to more negative potentials, explaining altered calcium dynamics in malignant hyperthermia.
Dietze et al. (2000) studied this question.
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