October 1, 1989AJP Cell Physiology

Effects of the halothane-sensitivity gene on sarcoplasmic reticulum function

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Population

Pigs of three genotypes regarding the halothane-sensitivity gene

Comparison

Halothane-sensitivity gene (genetic model) vs Homozygous normal allele pigs

Design

Preclinical

Authors

JMJames R. MickelsonWashington State University EGEsther M. GallantAustralian National University WRW. E. RempelAlbert Einstein College of Medicine

Discussion

Member takes

Implication

Animal data link halothane sensitivity to altered ryanodine receptor function in pigs; leaves open confirmation and clinical relevance in humans.

Structured PICO

Population

Pigs of three genotypes regarding the halothane-sensitivity gene (homozygous halothane-sensitive, homozygous normal, and heterozygous)

Intervention

Halothane-sensitivity gene (genetic model)

Comparator

Homozygous normal allele pigs

Outcome

Rate of calcium release from heavy sarcoplasmic reticulum and binding affinity of [3H]ryanodinesurrogate

The halothane-sensitivity gene alters sarcoplasmic reticulum calcium release and ryanodine binding, suggesting its protein product is closely associated with or identical to the SR calcium release channel-ryanodine receptor.

Cite This Study

Mickelson et al. (1989) studied this question.

synapsesocial.com/papers/6a756ea296d04a2f43f59b16 https://doi.org/10.1152/ajpcell.1989.257.4.c787

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Implication

Animal data link halothane sensitivity to altered ryanodine receptor function in pigs; leaves open confirmation and clinical relevance in humans.

Effects of the halothane-sensitivity gene on sarcoplasmic reticulum function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of the halothane-sensitivity gene on sarcoplasmic reticulum function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider