Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 22, 2007HepatologyOpen Access

Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the presence of fatty liver associate with left ventricular energy metabolism alterations and increased epicardial fat in young nondiabetic men?

Population

42 young, nondiabetic men matched for anthropometric features, with (n=21) or without (n=21) fatty liver.

Comparison

Presence of fatty liver vs Absence of fatty liver

Design

Case-control

Authors

GPGianluca PerseghinUniversity of MilanGLGuido LattuadaFondazione LanzaFCFrancesco De CobelliCardiac Imaging

Discussion

Loading...

Member takes

Implication

Fatty liver associates with epicardial fat and impaired myocardial energetics in young nondiabetic men; hypothesis-generating for early cardiac effects before structural change.

Structured PICO

Does the presence of fatty liver associate with left ventricular energy metabolism alterations and increased epicardial fat in young nondiabetic men?

P
Population
42 young, nondiabetic men matched for anthropometric features, with (n=21) or without (n=21) fatty liver.
I
Intervention
Presence of fatty liver (assessed by hepatic 1H-MRS)
C
Comparator
Absence of fatty liver
O
Outcome
Left ventricular (LV) alterations of energy metabolism, structure, and function, and epicardial fat accumulationsurrogate

Young men with newly discovered fatty liver exhibit increased epicardial fat and impaired left ventricular energy metabolism despite normal cardiac structure and function.

Cite This Study

Perseghin et al. (2007) studied this question.

synapsesocial.com/papers/6a714714e5469ee92be1db68https://doi.org/10.1002/hep.21983
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men2002 · 1,086 citations
  2. 2Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes2006 · 170 citations
  3. 3Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease2005 · 3,547 citations
  4. 4Cross-Sectional Assessment of the Effect of Kidney and Kidney-Pancreas Transplantation on Resting Left Ventricular Energy Metabolism in Type 1 Diabetic-Uremic Patients2005 · 63 citations
  5. 5Nonalcoholic Fatty Liver Disease2002 · 5,216 citations