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April 1, 1984Endocrinology

Production of Anti-Müllerian Hormone: Another Homology between Sertoli and Granulosa Cells

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Authors

BVB. VigierCentre Hospitalier Universitaire de RennesJPJean‐Yves PicardSorbonne UniversitéDTDien TranInserm

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Implication

In vitro study demonstrates bioactive anti-Müllerian hormone production in bovine granulosa cells, highlighting functional homology with testicular Sertoli cells.

Key Points

  • To determine whether adult bovine granulosa cells produce bioactive and immunoreactive anti-Müllerian hormone in a manner homologous to mature testicular Sertoli cells.
  • Measured anti-Müllerian hormone (AMH) concentrations via radioimmunoassay in bovine follicular fluid and granulosa cell incubation media.
  • Purified AMH from two distinct batches of bovine follicular fluid.
  • Tested bioactivity and antigenicity by culturing fetal rat Müllerian ducts with purified ovarian AMH alongside testicular AMH controls and probing with monoclonal and polyclonal antibodies.
  • AMH was purified from two independent follicular fluid batches with yields of 11% and 15%, respectively.
  • Both ovarian AMH and control testicular AMH triggered near-complete regression of cultured fetal rat Müllerian ducts at concentrations of 200–300 mU/ml and demonstrated identical antibody recognition.

Cite This Study

Vigier et al. (1984) studied this question.

synapsesocial.com/papers/6a71471d26a7f98052dda94ahttps://doi.org/10.1210/endo-114-4-1315
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localization of Anti-Müllerian Hormone in the Rough Endoplasmic Reticulum of the Developing Bovine Sertoli Cell Using Immunocytochemistry with a Monoclonal Antibody1982 · 92 citations
  2. 2Enhancing anti-Müllerian hormone processing reduces preantral follicle survival but spares female reproduction in mice2026
  3. 3Application of Anti-Müllerian Hormone in Regulation of Ovarian Function and Its Practical Relevance for Fertility and Embryo Production in Cows and Mares2026
  4. 4Anti-Müllerian Hormone in Veterinary Science: A Prospective Biomarker for Fertility and Productivity: A Review2025
  5. 5AMH regulates ovary size by counteracting ovarian follicle cluster effects.2024 · 2 citations