What question did this study set out to answer?

To evaluate the effectiveness of a pharmacist-led collaborative care model versus usual care for achieving target LDL levels in patients with coronary heart disease, and to assess the sustainability of effects following intervention withdrawal.

March 1, 2005Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Achieving Cholesterol Target in a Managed Care Organization (ACTION) Trial

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Authors

RSRobert J. StrakaUniversity of Minnesota System RTReza TaheriChapman University SCSusan L. CooperRegions Hospital

Discussion

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Implication

Prospective controlled study demonstrates improved cholesterol target attainment with pharmacist collaboration in heart disease patients, indicating durable treatment benefits.

Key Points

To evaluate the effectiveness of a pharmacist-led collaborative care model versus usual care for achieving target LDL levels in patients with coronary heart disease, and to assess the sustainability of effects following intervention withdrawal.
Prospective, multiclinic, controlled study conducted across four staff-model health maintenance organization clinics in Minneapolis and St. Paul, Minnesota (two intervention and two control clinics, balanced for urban and suburban settings).
Enrolled 481 patients aged 18 years or older with documented coronary heart disease whose LDL levels were not at goal (target ≤ 100 mg/dl).
Clinical pharmacists implemented physician-approved care plans involving lipid-lowering pharmacotherapy management and cardiovascular education, with evaluations at 6.5 months and 18 months post-intervention.
After a mean follow-up of 6.5 months, 107 (72%) patients in the intervention group versus 61 (18%) in the usual care group attained an LDL of ≤ 100 mg/dl (p<0.001).
Mean LDL reductions were 35.6 mg/dl (27.5%) in the intervention group compared with 6.7 mg/dl (4.6%) in the control group (p<0.001).
At 18 months after the collaborative program was discontinued, 85 (65%) intervention patients maintained their LDL goal compared to 96 (42%) control patients (p<0.001).

Cite This Study

Straka et al. (2005) studied this question.

synapsesocial.com/papers/6a714964e5469ee92be1dd64 https://doi.org/10.1592/phco.25.3.360.61601

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Implication

Prospective controlled study demonstrates improved cholesterol target attainment with pharmacist collaboration in heart disease patients, indicating durable treatment benefits.

Achieving Cholesterol Target in a Managed Care Organization (ACTION) Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Achieving Cholesterol Target in a Managed Care Organization (ACTION) Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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