Why the study?
What are the IgG subclass responses to AAV infection and vector administration in human subjects?
Population
Normal human subjects exposed to wild-type AAV, subjects injected intramuscularly with AAV vectors, and…
Design
Cross-sectional
Authors
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IgG subclass patterns after AAV exposure may inform vector selection; leaves open optimal monitoring strategies pending prospective validation.
What are the IgG subclass responses to AAV infection and vector administration in human subjects?
Human IgG subclass responses to AAV capsid exhibit a complex, non-uniform pattern with IgG1 being dominant, which can mask differences in other subclasses.
Murphy et al. (2008) studied this question.