Why the study?
Does intravenous alpha-hANP increase natriuresis and lower blood pressure in DOCA-salt hypertensive rats compared to control rats?
Does intravenous alpha-hANP increase natriuresis and lower blood pressure in DOCA-salt hypertensive rats compared to control rats?
DOCA-salt hypertensive rats exhibit an enhanced natriuretic and hypotensive responsiveness to alpha-hANP compared to controls.
No immediate clinical implications from this animal model; leaves open ANP responsiveness in human salt-sensitive hypertension.
Both natriuretic and hypotensive effects of alpha-human atrial natriuretic polypeptide (alpha-hANP) were investigated in anaesthetized DOCA-salt hypertensive rats and control rats. An intravenous injection of two doses (0.3 and 3.0 micrograms/kg body weight) of alpha-hANP produced a rapid and marked increase in natriuresis and fall in blood pressure in DOCA-salt rats. Natriuretic and hypotensive effects of alpha-hANP in DOCA-salt rats were significantly greater than those in the control rats. It is suggested that DOCA-salt rats may have an enhanced natriuretic and hypotensive responsiveness to alpha-hANP.
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Kondo et al. (1986) studied this question.