April 19, 2002Circulation ResearchOpen Access

Na + -H + Exchanger Inhibition

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Population

Models of cardiac hypertrophy including hypertensive myocardium, aortic constriction-induced hypertrophy…

Design

Review

Authors

HCHoracio E. CingolaniCentro de Investigaciones Cardiovasculares MHMarı́a C. Camilión de HurtadoBoehringer Ingelheim (Germany)

Discussion

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Implication

NHE inhibition represents a potential pharmacological target for preventing or regressing cardiac hypertrophy by modulating MAPK signaling pathways.

Structured PICO

Population

Models of cardiac hypertrophy including hypertensive myocardium, aortic constriction-induced hypertrophy, postinfarction myocardial hypertrophy, and cultured neonatal cardiomyocytes

Intervention

Na+-H+ exchanger (NHE) inhibition

Outcome

Prevention of stretch-induced MAPK stimulation and cardiac hypertrophysurrogate

NHE inhibition represents a potential pharmacological target for preventing or regressing cardiac hypertrophy by modulating MAPK signaling pathways.

Cite This Study

Cingolani et al. (2002) studied this question.

synapsesocial.com/papers/6a714c8435aa2c282ce29b5a https://doi.org/10.1161/01.res.0000016836.24179.ae

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Implication

NHE inhibition represents a potential pharmacological target for preventing or regressing cardiac hypertrophy by modulating MAPK signaling pathways.

Na + -H + Exchanger Inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Na + -H + Exchanger Inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider