N'-beta-phenethylformamidiny-liminourea (DBI), a synthetic substance, administered parenterally or orally, causes hypoglycemia in guinea-pigs, rats, rabbits, cats and Rhesus monkeys. It can also reduce blood sugar in alloxan-diabetic rats, rabbits and monkeys and maintain them at a normal level. DBI does not cause significant changes in glycogen content of liver or muscle. Further work will be necessary to elucidate its mechanism of action and assess its possible clinical usefulness.
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Ungar et al. (1957) studied this question.