Why the study?
Does adrenergic receptor stimulation alter coronary hemodynamics, myocardial oxygen consumption, and metabolic substrate preference in dogs with pacing-induced dilated cardiomyopathy?
Population
19 conscious, instrumented dogs with pacing-induced advanced dilated cardiomyopathy (DCM)
Comparison
Administration of norepinephrine, dobutamine… vs Control state (prior to pacing-induced DCM)
Design
Preclinical
Follow-up
4-5 weeks after initiation of pacing
Authors
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May increase oxygen demand via beta2 stimulation in DCM; leaves open whether selective adrenergic modulation merits testing in heart failure models.
Does adrenergic receptor stimulation alter coronary hemodynamics, myocardial oxygen consumption, and metabolic substrate preference in dogs with pacing-induced dilated cardiomyopathy?
Beta2-adrenergic receptor stimulation in dilated cardiomyopathy shifts myocardial metabolism toward free fatty acid oxidation, increasing oxygen requirements, which may be deleterious.
Lazaros A. Nikolaidis (2002) studied this question.
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