Procalcitonin as an Early Marker of Colorectal Anastomotic Leakage in Postoperative Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

Background The timely identification of colorectal anastomotic leakage (CAL) is still a significant challenge, and identifying reliable markers is essential to minimize patient morbidity and mortality. While procalcitonin (PCT) has shown promise as a biomarker for CAL, its effectiveness must be specifically evaluated in colorectal cancer patients. This systematic review and meta-analysis sought to assess the mean differences in PCT levels between individuals with and without CAL who underwent colorectal surgery for colorectal cancer. Methodology A comprehensive search of the "PubMed," "Scopus," and "Web of Science" databases was carried out, covering studies published through April 2024. The objective was to identify studies examining PCT levels in colorectal cancer patients who underwent colorectal surgery, with a particular focus on the occurrence of CAL. Data on the mean of PCT levels in CAL and non-CAL patients were extracted from the selected studies. The mean differences in PCT levels were subsequently analyzed for each postoperative day (POD). Results Seventeen articles were selected for inclusion in this systematic review. The statistical analysis included five eligible articles that assessed PCT levels in groups exclusively involving patients with colorectal cancer. The findings showed no significant increase in PCT levels in CAL patients compared to non-CAL patients on any POD when a leave-one-out sensitivity analysis was performed to validate the results. Conclusions To date, PCT levels should not be regarded as early indicators of CAL after colorectal surgery in patients with colorectal cancer. Additional research is necessary to evaluate if PCT could be a dependable marker for CAL in this particular setting.