Key result
Procalcitonin levels on day 1 after colorectal surgery accurately predicted anastomotic leakage (AUC 0.94; 95% CI 0.89-0.98), whereas interleukin-6 was not a significant early marker.
Why the study?
Does measurement of procalcitonin and interleukin-6 on postoperative day 1 predict anastomotic leakage in patients undergoing major elective colorectal surgery?
Population
157 patients undergoing major elective colorectal surgery
Design
Cohort
Authors
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May support early PCT monitoring for anastomotic leakage risk after colorectal surgery; hypothesis-generating and requires prospective validation before practice change.
Observational (n=157)
Does measurement of procalcitonin and interleukin-6 on postoperative day 1 predict anastomotic leakage in patients undergoing major elective colorectal surgery?
Effect estimate: AUC 0.94 (95% CI 0.89-0.98)
Absolute Event Rate: 2.73% vs 0.2%
p-value: p=<0.001
Procalcitonin measured on postoperative day 1 is a highly sensitive and specific early marker for predicting anastomotic leakage after major colorectal surgery, whereas IL-6 is not.
Zielińska-Borkowska et al. (2016) conducted an observational in Anastomotic leakage after colorectal surgery (n=157). Procalcitonin (PCT) and interleukin-6 (IL-6) levels vs. Patients without anastomotic leakage was evaluated on Anastomotic leakage (AL) (AUC 0.94, 95% CI 0.89-0.98, p=<0.001). Procalcitonin levels on day 1 after colorectal surgery accurately predicted anastomotic leakage (AUC 0.94; 95% CI 0.89-0.98), whereas interleukin-6 was not a significant early marker.
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