Why the study?
How the three states of myosin heads in the thick filament are controlled remains uncertain.
Population
Skeletal muscle myofibrils
Comparison
Mavacamten vs PKA phosphorylation
Design
Preclinical single-molecule imaging study
Authors
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SRX mapping refines thick-filament regulation models; leaves open its control in cardiac contractility.
Single-molecule imaging demonstrates that mavacamten increases the super-relaxed state of myosin heads in skeletal muscle, though its effect is limited across the sarcomere, while PKA phosphorylation has the opposite effect.
Pilagov et al. (2022) studied this question.
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