The diversified biological properties of streptovaricin complex likely reside in different molecular structures, as fractionated components show enhanced antiviral activity against Friend virus compared to pure streptovaricins.
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Fractionated streptovaricin components may enhance antiviral potency in animal models; leaves open whether specific structures drive retroviral activity.
Chromatographic fractionation of streptovaricin complex yields two stable components enriched (4- to 16-fold) in activity directed against the polycythemic strain of Friend virus; both components apparently contain no streptovaricins. When compared with their unfractionated parent streptovaricin complex, eight individual intact streptovaricins (A through G and J) show at least a 30-fold reduction in antiviral activity. These results further support the conclusion that the diversified biological properties of streptovaricin complex probably reside in different molecular structures.
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Horoszewicz et al. (1975) studied this question.
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