Key result
9-methylstreptimidone inhibits viral growth at 0.02 mcg/ml in vitro and demonstrates bioretention in mice.
Why the study?
A new antiviral agent inhibiting poliovirus, VSV, and NDV growth was isolated from Streptomyces culture filtrate and characterized.
9-methylstreptimidone is a newly isolated antiviral antibiotic that demonstrates inhibition of several viruses, including poliovirus, in vitro and in vivo.
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Not ready for clinical use; leaves open further evaluation of this microbial antiviral lead.
Saito et al. (1974) studied Viral infection (preclinical). 9-methylstreptimidone was evaluated on Minimum inhibitory concentration (MIC) for viral plaque formation and acute LD50 in mice. 9-methylstreptimidone, a newly isolated antibiotic, inhibited the growth of poliovirus, vesicular stomatitis virus, and Newcastle disease virus at 0.02 mcg/ml in vitro and demonstrated bioretention in mice.
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