Why the study?
Does SCH 48973 demonstrate antiviral activity against enteroviruses in vitro and in a murine poliovirus model?
Population
In vitro picornaviruses and human enterovirus isolates, and a murine poliovirus model of enterovirus disease
Design
Preclinical
Authors
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Hypothesis-generating for enterovirus therapy; leaves open clinical translation and human safety.
Does SCH 48973 demonstrate antiviral activity against enteroviruses in vitro and in a murine poliovirus model?
SCH 48973 is a potent, broad-spectrum antienterovirus compound with demonstrated in vitro activity and in vivo efficacy in a murine model.
Buontempo et al. (1997) studied this question.
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