Key result
Compound 1 and its analogue exhibited broad-spectrum antiviral activity against enteroviruses by directly inhibiting host factor PI4KIIIβ, and showed dose-dependent protection in a mouse pancreatitis model.
Population
In vitro cell cultures and a coxsackievirus serotype B4-induced pancreatitis mouse model
Design
Preclinical
Authors
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Supports PI4KIIIβ inhibition for enterovirus antivirals; leaves open translation from mouse models to patients.
A novel inhibitor targeting host cell factor PI4KIIIβ demonstrates broad-spectrum antiviral activity against enteroviruses in vitro and protective efficacy in a preclinical mouse model.
Schaar et al. (2013) studied Enterovirus infections. Compound 1 and its analogue was evaluated on Antiviral activity and PI4KIIIβ inhibition. Compound 1 and its analogue exhibited broad-spectrum antiviral activity against enteroviruses by directly inhibiting host factor PI4KIIIβ, and showed dose-dependent protection in a mouse pancreatitis model.
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