Population
In vitro translation-replication system for poliovirus, coxsackievirus B3, and encephalomyocarditis virus…
Design
Preclinical
Authors
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Hypothesis-generating for broad-spectrum picornavirus antivirals; further preclinical and clinical studies required before human translation.
Three novel small-molecule inhibitors effectively block picornavirus replication in vitro and show potential in vivo, with two compounds being highly refractory to viral resistance.
Ford-Siltz et al. (2014) studied this question.
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