Key result
Compound 14 significantly reduced mortality at an oral dose of 4 mg/kg in mice infected with poliovirus-2 and prevented paralysis in mice infected with ECHO-9 virus.
Population
Mice infected intracerebrally with poliovirus-2 and mice infected subcutaneously with a lethal dose of…
Design
Preclinical
Authors
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Supports advancement to human trials for picornavirus infections; leaves open efficacy and safety from animal data alone.
Compound 14 demonstrates significant in vivo efficacy against picornaviruses in mouse models, making it a candidate for clinical evaluation.
DIANA et al. (1985) studied Picornavirus infections. Compound 14 was evaluated on Mortality and paralysis. Compound 14 significantly reduced mortality at an oral dose of 4 mg/kg in mice infected with poliovirus-2 and prevented paralysis in mice infected with ECHO-9 virus.
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