Population
In vitro human rhinovirus serotypes (10 initially, then 84 additional) and monkey liver microsomes
Comparison
Biphenyl analogs of 5-[5-pentyl]-3-methylisoxazole vs Compound 2 (5-[5-pentyl]-3-methylisoxazole)
Design
Preclinical
Authors
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Promising preclinical profile for broad rhinovirus coverage; leaves open translation to clinical use.
Compound 6s demonstrates potent in vitro activity against human rhinovirus with improved metabolic stability compared to its predecessor.
Guiles et al. (1995) studied this question.
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