Population
Human rhinovirus type 1A and 14 (in vitro/crystallography model)
Comparison
Tetrazole analogues of Win 54954 vs Win 54954
Design
Preclinical
Authors
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Should not change rhinovirus management; leaves open further development of tetrazole analogues pending clinical validation.
Compound 16b, a tetrazole analogue, shows improved broad-spectrum antipicornavirus activity compared to Win 54954.
DIANA et al. (1993) studied this question.
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