Population
Human rhinovirus type 14 (HRV-14) and 14 additional serotypes in vitro
Comparison
Heterocyclic analogs of Win 54954 vs Win 54954
Design
Preclinical
Authors
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Compound 37 merits further lead optimization; QSAR leaves open the predictive value of physicochemical parameters for this series.
Compound 37 showed comparable antirhinoviral activity to Win 54954 in vitro, though QSAR analysis failed to explain activity differences among analogs.
Bailey et al. (1992) studied this question.
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