July 1, 1995Acta Crystallographica Section D Biological Crystallography

Structures of four methyltetrazole-containing antiviral compounds in human rhinovirus serotype 14

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Population

Human rhinovirus serotype 14

Comparison

Four novel antiviral WIN compounds containing a… vs Previously examined WIN compounds

Design

Preclinical

Authors

VGVincent L. GirandaMerck & Co., Inc., Rahway, NJ, USA (United States)GRGiovanni RussoSalesian Pontifical University PFPeter J. FelockTufts University

Discussion

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Implication

These distinct VP1 binding modes may guide rhinovirus antiviral optimization; hypothesis-generating and should not yet change practice.

Structured PICO

Population

Human rhinovirus serotype 14

Intervention

Four novel antiviral WIN compounds containing a methyl tetrazole ring as well as isoxazole, pyridazine or acetylfuran rings

Comparator

Previously examined WIN compounds

Outcome

Structural determination at 2.9 A resolution and binding position in the VP1 hydrophobic pocket

Structural analysis reveals that novel methyltetrazole-containing WIN compounds bind differently in the VP1 pocket of human rhinovirus 14, potentially explaining differences in antiviral potency.

Cite This Study

Giranda et al. (1995) studied this question.

synapsesocial.com/papers/6a87cd750112b7b407bb50db https://doi.org/10.1107/s0907444994011674

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Structures of four methyltetrazole-containing antiviral compounds in human rhinovirus serotype 14

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structures of four methyltetrazole-containing antiviral compounds in human rhinovirus serotype 14

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider