May 1, 1988Proceedings of the National Academy of SciencesOpen Access

Structural analysis of a series of antiviral agents complexed with human rhinovirus 14.

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Population

Human rhinovirus 14 and its drug-resistant mutants

Design

Preclinical

Authors

JBJohn BadgerStephens College IMIwona MinorUniversity of Wisconsin–Madison MKMarcia J. KremerJanssen (Belgium)

Discussion

Member takes

Implication

Unifies rhinovirus antiviral mechanisms via shared VP1 pocket; leaves open potency determinants for therapeutic optimization.

Structured PICO

Population

Human rhinovirus 14 and its drug-resistant mutants

Intervention

A series of eight antiviral agents that inhibit picornaviral uncoating

Outcome

Binding characteristics and conformational changes on the virionsurrogate

Crystallographic analysis reveals that eight antiviral agents bind to the same hydrophobic pocket in human rhinovirus 14, inhibiting disassembly by reducing protein shell flexibility.

Cite This Study

Badger et al. (1988) studied this question.

synapsesocial.com/papers/6a85a22802a1bc3ea31e6d20 https://doi.org/10.1073/pnas.85.10.3304

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Structural analysis of a series of antiviral agents complexed with human rhinovirus 14.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural analysis of a series of antiviral agents complexed with human rhinovirus 14.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider