April 1, 2015Antiviral chemistry & chemotherapyOpen Access

Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds

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Population

In vitro cell cultures infected with human pathogenic enteroviruses

Comparison

Pleconaril/pirodavir-like compounds vs Reference drug pleconaril and untreated infected…

Design

Preclinical

Authors

ABAngela M. BernardUniversity of Cagliari CLCéline LacroixUniversité Claude Bernard Lyon 1 MCMaria Grazia CabidduIstituto Nazionale di Fisica Nucleare, Sezione di Cagliari

Discussion

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Implication

These analogs merit preclinical development; leaves open clinical efficacy against enteroviruses.

Structured PICO

Population

In vitro cell cultures (HeLa Rh, BGM, Vero, and RD cells) infected with human pathogenic enteroviruses (Enterovirus 71, Coxsackievirus B3, Poliovirus 1, Echovirus 11, Rhinovirus 14)

Intervention

Pleconaril/pirodavir-like compounds (series [6c-10c] and [6002-6702])

Comparator

Reference drug pleconaril and untreated infected controls

Outcome

Antiviral activity measured by 50% effective concentration (EC50) and selectivity index (SI) in a virus-cell-based cytopathogenic effect (CPE) reduction assaysurrogate

Novel pleconaril/pirodavir-like compounds demonstrate potent and selective in vitro antiviral activity against several enterovirus species, including EV71, PV1, and ECHO11.

Cite This Study

Bernard et al. (2015) studied this question.

synapsesocial.com/papers/6a9097432a22b8e8a92db992 https://doi.org/10.1177/2040206615589035

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Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider