May 8, 2013ACS Medicinal Chemistry LettersOpen Access

Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections

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Population

In vitro models of human rhinovirus, Coxsackie virus, poliovirus, enterovirus-71, and hepatitis C replicon…

Design

Preclinical

Authors

AMAngus M. MacLeodHertfordshire Community NHS Trust DMDale R. MitchellCellCentric (United Kingdom)NPNicholas J. PalmerUniversity of East Anglia

Discussion

Member takes

Implication

Supports PI4KIIIβ as antiviral target; animal data leave open human translation.

Structured PICO

Population

In vitro models of human rhinovirus, Coxsackie virus, poliovirus, enterovirus-71, and hepatitis C replicon assay

Intervention

A series of potent, broad-spectrum antiviral compounds (PI4KIIIβ inhibitors)

Outcome

Inhibition of viral replicationsurrogate

A newly identified series of compounds demonstrates potent, broad-spectrum antiviral activity against enteroviruses by inhibiting the lipid kinase PI4KIIIβ.

Cite This Study

MacLeod et al. (2013) studied this question.

synapsesocial.com/papers/6a87cd750112b7b407bb50d5 https://doi.org/10.1021/ml400095m

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Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider