Key result
Compound 6g potently inhibited the replication of hRV-B14, A21, and A71 with EC50 values of 0.083, 0.078, and 0.015 μM, respectively, by interacting with the viral capsid protein.
Population
Human rhinoviruses and poliovirus 3 in vitro models
Design
Preclinical
Authors
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* Since it's an animal/in vitro study (.
A novel series of benzothiophene derivatives, particularly compound 6g, demonstrated potent in vitro inhibition of rhinovirus and poliovirus replication by targeting the viral capsid protein.
Kim et al. (2017) studied Human rhinovirus infection. Benzothiophene derivatives (Compound 6g) was evaluated on Inhibition of rhinovirus replication (EC50). Compound 6g potently inhibited the replication of hRV-B14, A21, and A71 with EC50 values of 0.083, 0.078, and 0.015 μM, respectively, by interacting with the viral capsid protein.
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