7-deaza-2'-C-methyladenosine demonstrates potent in vitro antiviral activity against multiple diarrhea-causing viruses by inhibiting viral polymerase.
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Should not yet change practice for viral diarrhea; leaves open nucleoside analogue development for enteric viruses.
A safe and highly efficient antiviral is needed for the prophylaxis and/or treatment of viral diarrhea. We here demonstrate the in vitro antiviral activity of four 2'-C-methyl nucleoside analogues against noro-, rota-, and sapoviruses. The most potent nucleoside analogue, 7-deaza-2'-C-methyladenosine, inhibits replication of these viruses with a 50% effective concentration < 5 µM. Mechanistically, we demonstrate that the 2'-C-methyl nucleoside analogues act by inhibiting transcription of the rotavirus genome. This provides the first evidence that a single viral-diarrhea-targeted treatment can be developed through a viral-polymerase-targeting small molecule.
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Dycke et al. (2018) studied this question.
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