Why the study?
Cardiovascular pathology is a frequent comorbidity in patients with COPD, with endothelial dysfunction serving as an early phase of pathogenesis.
Endothelial dysfunction and oxidative stress play a crucial early role in the pathogenesis of cardiovascular comorbidities in patients with COPD.
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May inform risk stratification in COPD-CVD overlap; leaves open interventional trials targeting endothelial pathways.
Cardiovascular pathology is one of the frequent comorbidities in patients with chronic obstructive pulmonary disease, due to both genetic predisposition and common risk factors (smoking, senile age, male gender, sedentary lifestyle, obesity). The article shows that development of endothelial dysfunction is one of the earliest phases of pathogenesis in this setting. Endothelial dysfunction mechanisms are defined and characterized, including an imbalance of vasoconstricting and vasodilating agents with the emergence of "vicious circles" that violate hemo-vascular homeostasis. The role of nitric oxide, endothelin-1, intercellular adhesion molecule-1 (ICAM-1) in the development of endothelial dysfunction in COPD patients is discussed. The article defines the concept of oxidative stress, the most potent oxidants and mechanisms of their damaging effect arebeing listed. A particular attention is paid to 8-isoprostane as a golden standard in assessment of oxidative stress in patients with COPD.
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Ащеулова et al. (2021) studied this question.
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