October 30, 2008AJP Regulatory Integrative and Comparative Physiology

Tissue-specific postprandial clearance is the major determinant of PPARγ-induced triglyceride lowering in the rat

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Why the study?

Does PPARgamma agonism improve tissue-specific postprandial triglyceride clearance in rats on an obesogenic diet?

Population

Rats fed an obesogenic diet

Design

Preclinical

Follow-up

3 weeks

Authors

MLMathieu LaplantePROTEO WFWilliam T. FestucciaInstitute of Biomedical Science GSGeneviève SoucyCentre Hospitalier de l’Université de Montréal

Discussion

Member takes

Implication

No direct clinical implications; extends mechanistic insights on PPARγ agonism and adipose LPL in obese rat models.

Structured PICO

Does PPARgamma agonism improve tissue-specific postprandial triglyceride clearance in rats on an obesogenic diet?

Population

Rats fed an obesogenic diet

Intervention

PPARgamma full agonist COOH (30 mg.kg(-1).day(-1)) for 3 weeks

Outcome

Hepatic VLDL-TG secretion rate and tissue-specific TG clearancesurrogate

In a diet-induced obesity rat model, PPARgamma agonism lowers triglycerides primarily by increasing postprandial lipid uptake in specific adipose depots, mediated by lipoprotein lipase.

Cite This Study

Laplante et al. (2008) studied this question.

synapsesocial.com/papers/6a7151c9febe604dd70a010f https://doi.org/10.1152/ajpregu.90552.2008

View Full Paper

Ask AI

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Tissue-specific postprandial clearance is the major determinant of PPARγ-induced triglyceride lowering in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tissue-specific postprandial clearance is the major determinant of PPARγ-induced triglyceride lowering in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider